Ken Shirriff -> AIDS theories -> CpG motifs |
Location of CpG dinucleotides in the HIV-1 genome. The location of each CpG in the HIV genome is indicated by a vertical line, with a histogram showing the numbers of CpGs in each region above. The majority of the CpGs is clustered near the 5' and 3' ends of the genome. Only 0.88% of the dinucleotides are CpG, compared with 6.25% expected, assuming random base usage (the HIVBRUCG sequence was analyzed). The profound CpG suppression in the HIV genome may help the retrovirus to avoid activating the CpG host-defense mechanism. |
Reference:
A. Krieg, ``Lymphocyte activation by CpG
dinucleotide motifs in prokaryotic DNA,'' Trends in Microbiology, 4(2),
Feb. 1996, p. 75.
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